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Nicotine and vape withdrawal timeline

Checked against the sources at the bottom on 2026-10-15. This is general information, not medical advice.

Vapes and cigarettes both deliver nicotine, so quitting either one can bring on nicotine withdrawal. The CDC says quitting vaping is likely similar to quitting smoking because both involve nicotine addiction. Most of the timing research below comes from people who quit cigarettes. The few studies of vapers so far show a similar early pattern.

The short answer

The National Cancer Institute (NCI) says withdrawal symptoms are usually worst during the first week after quitting and peak in the first 3 days. Their intensity usually drops over the first month, though some people have symptoms for several months.

A 2007 review by John Hughes, based on about 120 studies, found that the core withdrawal symptoms peak within the first week and last 2 to 4 weeks. Smokefree.gov says the worst symptoms last a few days to a couple of weeks.

Symptoms

Hughes judged these to be valid withdrawal symptoms: anger, anxiety, depression, difficulty concentrating, impatience, insomnia and restlessness. The NCI adds cravings and increased hunger to the common list. Less common ones include headaches, fatigue, dizziness, coughing, mouth ulcers and constipation.

The Smokefree.gov page for people quitting vaping lists feeling irritable, restless or jittery, headaches, feeling sad or down, anxiety, feeling tired or groggy, trouble concentrating, trouble sleeping, more hunger than usual and strong cravings to vape.

Timeline

Time since last nicotine What studies and health agencies report
First few hours In a small study of 15 people who vaped but had never smoked, craving rose within 90 minutes, and withdrawal symptoms showed up within 2 to 3 hours (Felicione 2022).
Day 1 Tension, agitation and low mood can start within the first day (NCI).
Days 1 to 3 Symptoms usually peak (NCI). In a study of former smokers who vaped, withdrawal peaked on day 1 or 2 (Hughes 2019).
Days 4 to 7 Still part of the worst week (NCI). Among the vapers in Hughes's 2019 study, scores were slowly falling by this point.
Weeks 2 to 4 Core symptoms fade over 2 to 4 weeks (Hughes 2007), and intensity usually drops over the first month (NCI).
Months later Some people have symptoms for several months, and occasional mild cravings can show up months or years after quitting (NCI).

What studies of vapers show

In a 2019 trial, Hughes and colleagues asked former smokers who used refillable tank e-cigarettes every day to vape as usual for a week and then stop for six days, with breath and urine tests to check. Of 109 people enrolled, 59 followed the protocol well enough to be analyzed. Withdrawal rose after they stopped, peaked on day 1 or 2, and then slowly fell. Irritability, restlessness, anxiety, appetite and trouble concentrating all went up. By day 6, 41% still had higher scores than before they quit.

The authors estimated this withdrawal was about 25% milder than in an earlier study of people quitting cigarettes, but they warned that comparisons across studies can mislead. The study was not blinded, lasted only six days, and excluded JUUL users, so it may not reflect people who use pod devices or who never smoked.

The 2022 study of 15 never-smokers was even shorter: two 3-hour sessions, one vaping as usual and one without. The authors called it a preliminary evaluation.

Focus and concentration

Hughes grouped difficulty concentrating with the other core symptoms that peak in the first week and fade over 2 to 4 weeks. A 2014 review linked nicotine withdrawal to problems with sustained attention, working memory and response inhibition, which is the ability to hold back an automatic response (Ashare and colleagues, 2014). In the small study of vapers who never smoked, a test of inhibitory control was worse after 2 hours without vaping (Felicione 2022).

What helps

The CDC says the FDA has approved seven medicines to help people quit smoking, and that they can double the chance of quitting for good.

For vaping, Smokefree.gov says nicotine replacement therapy, varenicline and bupropion can reduce cravings and withdrawal symptoms, but the FDA has not approved them to help people quit vaping. Ask a doctor or other health professional whether one makes sense for you.

Smokefree.gov also suggests drinking water through the day, keeping a regular sleep schedule, limiting caffeine and alcohol, keeping healthy snacks nearby and making a plan for cravings before they hit.

Tracking your focus as the days add up

Fogless is a free quit tracker that runs in your browser. Next to the day counter, it has a one-minute brain check: a reaction time test (five taps, median kept), a number memory test that adds a digit each time you get one right, and a focus test where you tap the direction of the middle arrow. Your first check is your baseline of 100, and later checks are compared to it.

Scores also go up with practice (Bartels and colleagues, 2010) and drop with lost sleep (Lim and Dinges, 2010), so the trend over several weeks says more than any single day. Fogless does not diagnose anything and does not shorten withdrawal. There is no account, and your data stays on your device. The free version shows your last five checks; Pro ($4.99 a month or $29 a year) adds a trend line for each test, your average for each week since you quit, and the full history.

When to get help

FAQ

How long does nicotine withdrawal last?

The worst usually passes in less than two weeks (Smokefree.gov), and the core symptoms fade over 2 to 4 weeks. Some people notice symptoms for several months.

What is the worst day of nicotine withdrawal?

Usually somewhere in the first 3 days (NCI). Vapers in Hughes's 2019 study peaked on day 1 or 2.

Is quitting vaping harder than quitting cigarettes?

There is not enough research to say. One study of former smokers who vaped found withdrawal about 25% milder than in a past study of cigarette quitters, but the authors cautioned against comparing across studies.

Why am I so hungry after quitting nicotine?

Increased hunger is a common withdrawal symptom (NCI). In the 2019 vaping study, both appetite and weight went up within six days.

Do nicotine cravings ever go away?

They get less frequent. The NCI says cravings can come often for the first few days or weeks, and occasional mild cravings may show up months or years later.

If you want to watch your own focus and reaction time as the weeks go by, take your first brain check in Fogless. It takes about a minute and needs no account.

Sources

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Fogless runs a one-minute check of reaction time, memory and focus, and compares every result with your first one. Free, no signup.

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Need to talk to someone? SAMHSA's National Helpline is free, confidential and open 24/7 at 1-800-662-4357. In a crisis, call or text 988.